A new clinical research paper provides additional evidence that BeniCaros®, a functional food, beverage and supplement ingredient, prepares the immune system and strengthens healthy immune responses, NutriLeads BV announced. The research was recently published in the peer-reviewed journal Nutrients.
The research paper elaborates on previous findings that showed 300 mgs. of BeniCaros accelerated immune responses and significantly reduced the severity and duration of symptoms in a study of 146 healthy human subjects following a controlled challenge with a common cold virus. These latest data demonstrate that BeniCaros, a soluble prebiotic carrot fiber known scientifically as Rhamnogalacturonan-I or cRG-I, significantly reduced individual cold symptoms and helped subjects feel better and maintain their quality of life. The paper is titled, “Effects of Dietary Supplementation with Carrot-Derived Rhamnogalacturonan-I (cRG-I) on Accelerated Protective Immune Responses and Quality of Life in Healthy Volunteers Challenged with Rhinovirus in a Randomized Trial.”
“Subjects taking BeniCaros felt considerably better and reported significant reductions in common cold symptoms, including a runny nose, sore throat, coughing and feeling tired, compared with the placebo group,” said Ruud Albers, Ph.D., NutriLeads founder and Chief Scientific Officer. “The BeniCaros group also reported significantly better quality-of-life scores than the placebo group, including the ability to think clearly, exercise and accomplish daily activities and work inside and outside the home.”
BeniCaros has a dual mode of action that trains the immune system to respond faster, preparing innate immune cells for a heightened state of readiness, and selectively increases beneficial gut microorganisms and their metabolites that support immune responses.
“Our research shows that BeniCaros supports and accelerates healthy immune responses when they are needed most,” said Joana Carneiro, NutriLeads Chief Executive Officer. “These latest data illustrate the ways in which BeniCaros helps individuals live their lives so nothing slows them down.”
Study design
In the randomised, double-blind, placebo-controlled trial, 146 healthy adults were given either BeniCaros or a placebo for eight weeks, after which they were exposed to a standardised dose of a mild rhinovirus via the nose. Researchers utilised blood, fecal and nasal fluid samples to count immune cells, track blood markers, measure immune responses and investigate gene expression. In addition, a validated clinical questionnaire was used to evaluate common cold symptom severity and quality of life.
Subjects were asked to complete the Wisconsin Upper Respiratory Symptom Score-21 (WURSS-21) questionnaire every morning for two weeks starting the day before infection. WURSS-21 is comprised of 21 questions divided into three sections: total score and “how well do you feel today?”, upper respiratory tract infection symptoms, and quality-of-life questions to assess the impact of a common cold on daily activities.
Study results: BeniCaros reduced severity, duration & impact of cold symptoms
Subjects taking 300 mgs. of BeniCaros reported statistically significant reductions in symptom severity (20 – 33 %) and duration (28 – 43 %) compared with the placebo group, based on the total WURSS-21 over 13 days post infection. BeniCaros subjects experienced a lower peak value in severity (day 3) and lower impact (10 – 30 %) of a variety of common cold symptoms, including runny nose, sore throat, cough and feeling tired.
BeniCaros also significantly reduced the negative impact of a common cold on quality of life. In comparison with the placebo group, BeniCaros subjects reported that their colds interfered 10 – 30 % less with their quality of life. Key measurements included the ability to think clearly, walk, climb stairs, exercise, accomplish daily activities, work inside and outside the home and live their personal lives.
Biological study data show BeniCaros supports a cascade of protective immune responses in the presence of a health challenge. BeniCaros accelerated local and systemic immune response biomarkers, including critical anti-viral interferon gene expression and mobilisation of innate immune cells to the site (nasal cavities) of the challenge. Ex vivo stimulation of whole blood samples demonstrated that BeniCaros enhanced the function of natural killer cells, which play an important role in the early innate immune response to virus infections. Importantly, systemic immune responses following BeniCaros supplementation were unchanged in the absence of an immune challenge.
“BeniCaros trains the immune system to be ready to respond when it is challenged,” said Dr. Albers. “It does not lead to broad, non-specific activation of the innate immune system. It is important that immune-support products designed to be taken long term do not stimulate or boost the immune system unnecessarily.”
Five things to know about fruit juice, from experts at the Fruit Juice Science Centre
A poll1 of more than 3000 adults, commissioned by the Fruit Juice Science Centre, has found that two thirds of Brits (65 %) and more than a third of French and German adults (34 %) drink 100 % fruit juice to support their immune function. The beverage was most frequently listed after fruit and vegetables amongst the top immunity-support foods.
However, there was less awareness about the nutrients provided in fruit juice, with just half of adults overall agreeing that a daily glass is rich in vitamins and minerals. Fewer than a fifth in France and Germany, and a third in the UK, knew that antioxidants – such as vitamin C – can be found in fruit juice. And most didn’t realise that fruit juice contains polyphenols – beneficial plant compounds also found in fruit, vegetables, and cocoa.
With internet searches on vitamin C soaring during the pandemic, nevertheless four in ten Brits and Germans, and more than half of French didn’t know that vitamin C is necessary for healthy immune function. This is despite six in 10 being more aware of immune health since the pandemic.
Commenting on the survey, Dr Carrie Ruxton from the Fruit Juice Science Centre said: “Awareness of how a glass of fruit juice supports normal immunity has improved but there are still some misconceptions. Considering that 100 % juice is simply squeezed fruit – and has practically identical sugars, vitamins, and positive bioactive compounds compared with whole fruit – there is still a lot of nonsense claimed about fruit juice.
“A key myth is that sugar is added to fruit juice, which it isn’t since that would be illegal in the EU and UK. Another is that the vitamin C in packaged fruit juice is destroyed – that’s also untrue. Neither is it correct to say that pure fruit juice contains preservatives and colours, although thankfully only one in 10 people in our Poll believed that.”
Five facts on fruit juice – from the Fruit Juice Science Centre
- Just one small glass of 100 % fruit juice provides more than 80 % of the vitamin C recommendation. Vitamin C is an antioxidant and essential for normal immunity;
- Orange juice is one of the richest sources of hesperidin, a polyphenol that has anti-inflammatory effects;
- Fruit juice is high in potassium, a mineral that helps to control blood pressure;
- It takes one or two oranges to make a 150 ml glass of fruit juice and all the sugars in fruit juice come from the fruits used to make them – none is added;
- Apple, orange, and grapefruit juices are all low GI (glycaemic index) meaning that they raise blood sugars more slowly compared with high GI foods, such as rice, bread, or sugar-sweetened drinks.
How about sugar
The Fruit Juice Science Centre poll found that eight in 10 adults believe that 100 % fruit is not high in sugar. Additionally, a quarter of Brits (24 %) and Germans (28 %), and more than a third of French (35 %), think that pure fruit juice is actually low in sugar. The reality is that a typical glass of orange juice contains the same level of natural sugars (around 13 g) as a couple of oranges.
Dr Ruxton says: “Fruit juice is enjoyed by millions of people every day and most seem to recognise that it has a positive role in the diet. Given that most of the sugar we eat comes from sugar-sweetened drinks, biscuits, cakes, confectionery and desserts – foods which are low in essential nutrients – it’s clear where we need to turn our attention to cut sugar intakes.”
1Independent poll of 1029 UK adults, 1021 French adults and 1012 German adults; data on file.
Natural energy and performance recovery brand, Resync, announced the newest Resync beverage, the first vegan ready-to-drink multisystem support drink on the market. The Resync beverage offers a convenient and delicious way to support the heart, immune and digestive system all in one eleven-ounce sparkling beverage.
The Resync beverage brings together the most critical ingredients to support the primary functional systems of the body, including immunity-boosting vitamin C that provides 555 % of daily value; seven grams of plant fiber and prebiotics to strengthen gut health; 200 mg of phenolic antioxidants to aid proper heart and immune system function; and a plant-based nitric oxide blend to support the heart and provide natural energy.
“Although the idea for the Resync beverage predated Covid-19, the pandemic became both my motivation and demand-based rationale to create the first vegan- and one of the healthiest overall-ready-to-drink beverages on the market,” said Resync, LLC founder and CEO Barbara Depta. “It is important to me that my premium line of natural energy and recovery improvement products support a moderately-active senior just as much it does my pro-athlete clients. The Resync beverage, as well as the entire line of Resync products, are both suitable for and accessible to everyone, anywhere, anytime.”
The functional support provided in one eleven-ounce can of Resync beverage brings together what would normally require three separate and distinct consumable products for the heart, immune and digestive systems. The aronia citrus flavour of the Resync beverage was born of the combination of natural ingredients: aronia berries, one of nature’s most powerful antioxidants; red beets, which are packed with fiber, folate, manganese, potassium, iron, and vitamin C for improved blood flow; and high-quality red spinach, which supplies nitric oxide, a critical molecule in our bodies that aids in increased blood flow and energy.
In the creation of her product line, Depta discovered that nitric oxide, delivered on the cellular level through the vascular system, could help provide nutrients to the entire body to support energy, heart health, and brain functionality, while supporting healthy inflammatory response due to exercise. It supports many essential reactions underneath the skin and has the potential to relax and widen blood vessels, allowing for more effective and efficient blood flow, nutrient delivery throughout the body. The plant-based nitric oxide blend is the primary element of every product in the Resync line.
Resync RTD can be purchased on Resync’s website at resyncproducts.com. The eleven-ounce cans are sold in packs of 12 for $69.99, or $59.49 with a monthly subscription.
The Resync beverage joins a full line of natural energy and performance support drinks and blends developed on the basis of scientific research, with registered dietitians, and performance testing. Resync uses third party testing certification for their supplement line, including NSF Certified for Sport and BSCG, to ensure all products are safe and free of banned substances. The full line, which offers Resync Recovery Blend and Resync Premium Collagen Peptides, is non-GMO, gluten free, sugar free, contains no artificial sweeteners, and is keto friendly. Resync is the trusted brand of registered dietitians, doctors, coaches and athletes around the world.
About Resync
Barbara Depta created Resync in 2017 while she was traveling as a structural balance coach with one of the top NFL teams. Her goal was to develop products that didn’t exist for professional athletes and anyone who wants clinically tested, plant-based blends to sustain their energy, recover better post physical activity -products to help people feel their best, refuel their bodies, and support every layer of their connective tissue health.
